Docebenone CAS80809-81-0
AA-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. Inhibition of 5-LO has shown to accelerate and enhance fracture-healing and increase Ca2+ in MDCK cells by releasing Ca2+ from multiple internal stores. AA-861 has been used to probe fatty acid metabolism and leukotriene production, and inhibit the production of the slow reacting substance of anaphylaxis (SRS A) - which is thought to play an important role in asthmatic and inflammatory reactions