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Antibacterial paper—A magical paper created by chitosan and guanidine hydrochloride 2017-12-18 11:48:37

What is antibacterial paper?


Antibacterial paper is an important new type of paper-based material with function of killing or inhibiting microorganisms. It can be widely used in packaging of food and medicine, hospital paper, indoor environmental protection and cultural relics protection, etc. It can prevent various infectious diseases caused by the spread of harmful bacteria and cross-infection during paper use.



Through the ion-crosslinking method, researchers combined chitosan and high purity guanidine hydrochloride to prepare a nano-antibacterial agent, and used it for the manufacturing of new highly efficient antibacterial paper.


Chitosan is a natural antibacterial material extracted from the shell of marine crustaceans, which has the advantages of good safety, but has poor heat resistance, short effective time and narrow application range; guanidine hydrochloride (guanidinium chloride) not only has strongly alkaline, high stability and good biological activity, but also has good antibacterial properties.

The procedure is as follows:


(1) The chitosan powder was dissolved in a certain amount of acetic acid solution;
(2) Guanidine hydrochloride (guanidine HCl) solution (8g•L-1, 50mL) was mixed with sodium tripolyphosphate solution (2g•L-1, 40mL);

(3) chitosan solution was added to (2) slowly, then stirred at room temperature for 4h to prepare chitosan-guanidine hydrochloride nanoparticle emulsion to creat the paper.


In order to study the antibacterial properties of the new antibacterial paper, Escherichia coli and Staphylococcus aureus were selected as antibacterial objects and tested by the inhibition zone method. With the increase in the amount of antimicrobial agents, antibacterial effect increased. And when the amount of antibacterial agent was 3%, the inhibition zone reached the maximum.


As the antibacterial paper has two kinds of antibacterial agents chitosan and guanidine hydrochloride at the same time, it has a strong inhibitory effect on E. coli. and Staphylococcus aureus. Compared with antibacterial paper with single component, the antibacterial property of paper with chitosan and guanidine hydrochloride (CAS: 50-01-1) is increased.



In addition to the application on antibacterial paper, guanidine hydrochloride (Model No.: Y0010) is also a strong denaturant in the extraction of RNA experiments. It is an important intermediate for pharmaceuticals, pesticides, dyes and other organic compounds. It is an important raw material for the production of sulfonamides and folic acid. It can also be used as an antistatic agent for synthetic fibers.



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