Guanidine hydrochloride is often used as an intermediate in medicines, pesticides, dyes and other organic compounds, it is also an important raw material for sulfonamides and folic acid; it can be used as a strong denaturants in the extraction of total RNA from cells. The proportion of traditional refined guanidine hydrochloride synthetic preparation process is simple, and the operation in each process is not strict: such as mixing impurities during stirring, temperature is difficult to observe, and weighing is inaccurate. Both of them lead to the problem that the low purity of the Guanidine HCL and the incomplete reaction. Then how to solve these problems?

Researchers have developed a new guanidine hydrochloride synthetic preparation process, which solves the shortcomings of the prior part. As a preference, the following steps are included:

5. Preparation was completed, and the reaction vessel was opened to obtain 385 g of hydrazine hydrochloride.

The preparation process not only has a precise ratio, the reaction temperature is convenient for observation and control, no impurity is mixed during stirring, the reaction is complete, and the prepared guanidine hydrochloride is also high in purity.