Tris (Tromethamine) is well known as a kind of biobuffers for many biochemical experiments. In fact, it is also widely used in the medical field: It is a drug for acidosis, and an important pharmaceutical intermediate for a variety of drugs.

Biobuffer

Tris is alkaline, which can be prepared to buffers from acidic to alkaline only with HCl. Tris HCl CAS:1185-53-1 has the following advantages:

But with the following disadvantages:

Drug for Acidosis

As a drug, Tromethamine CAS 77-86-1 can be used for acute metabolic acidosis and acute respiratory acidosis. Because of sodium free, it is especially suitable for patients with heart failure, and the rescue of low-temperature anesthesia, shock and cardiac arrest. It also can be used to treat ischemic intracellular acidosis after organ transplantation.

Pharmaceutical intermediates

As an organic amine, tris (tromethamine) can form salts which is easily soluble in water with poorly soluble drugs having acidic groups. The representative drugs are dexketoprofen trometamol, fosfomycin tromethamine, carboprost tromethamine, ketorolac tromethamine.

• Dextroantrofen tromethamine: It is suitable for short-term pain of trauma and postoperative;
• Fosfomycin tromethamine: mainly used for the treatment of non-complex urinary tract infection;
• Carboprost tromethamine: mainly used for treatment for postpartum hemorrhage;
• Ketorolac tromethamine: It can be used to relieve pain of all symptoms.

Tris (tromethamine) is widely used in the biological field and medical field, whether used as biobuffer, drug, or pharmaceutical intermediate, Tris has played a huge role for the development of science and saving lives.