guanidine hydrochloride is often used as an intermediate in medicines, pesticides, dyes and other organic compounds, it is also an important raw material for sulfonamides and folic acid; it can be used as a strong denaturants in the extraction of total RNA from cells. At the same time, guanidine hydrochloride is often used in various buffers for biological experiments. Below, we will introduce its application in a kind of fluorescent probe with reactive high selectivity detection of hydrazine.
Hydrazine is an unstable and volatile colorless flammable liquid that plays an important role in medicine, pesticides, dyes, chemicals and aerospace. Hydrazine has carcinogenic, neurotoxic, visceral damage and other toxicities, easy to be absorbed by oral, skin, inhalation, etc., China's environmental protection law clearly stipulates the mass concentration of strontium, requires that the concentration of strontium in surface water and fishery water should not exceed 10.0μg/L. Therefore, the development of methods for rapid, simple, sensitive and selective detection of cesium is very important in the environmental and biological sciences.
Compared with the prior process, the present invention product 2-chloro N-(7,7-dimethyl-4-(2'-pyridine)-4,5,6,7-tetrahydro-6,8-bridged methylenequinazoline)acetamide was prepared from the natural renewable resource β-pinene derivative nopinone, which selectively reacts with hydrazine and emits violet fluorescence upon irradiation with 365 nm ultraviolet light. It can be used as a specific fluorescent probe for detecting nopinone and has good practicability.
[1] Fluorescent probe with reactive high selectivity detection enthalpy and preparation method and application thereof. CN109776492A, 2019-05-21.
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