As a drug, tromethamine 77-86-1 can be used to prevent and treat metabolic acidosis and respiratory acidosis, and has a reliable alkalizing effect on urine. However, because of the strong alkalinity, the preparation can only be injected intravenously, and the intravenous injection is relatively irritating and has many adverse reactions. In response to the shortcomings of the existing technology, Yunnan College of Traditional Chinese Medicine has prepared an organic salt of tromethamine, which can be taken orally and intravenously. Liquid, prevention and treatment of hyperuricemia and gout, and anti-peptic ulcer.

This tromethamine organic salt is prepared by using organic acid acetic acid or lactic acid which can be completely degraded by the body and tromethamine. The tromethamine organic salt solid or solution, after injection or oral, the acetic acid or soft acid can be completely and rapidly degraded, enter the liver in the form of salt, and get free tromethamine after being discharged Metabolized to carbon dioxide and water, acetic acid degrades faster than lactic acid. Because tromethamine has the characteristics of high polarity, stable chemical properties, and is not easily metabolized by the body, the tromethamine portion left in the human body can play a role of basifying blood.

Promoting renal excretion of uric acid is an important strategy for the prevention and treatment of hyperuricemia and gout. And tromethamine can basify the renal tubule environment, which can dissolve the deposited acidic substances and excrete the body.

In addition, this organic salt of tromethamine is a weakly alkaline substance, with a pH close to that of blood. Compared with the direct use of tromethamine, it has a low irritation, which can avoid or greatly alleviate the effects of excessive alkali Adverse reactions and safety issues. Moreover, the tromethamine organic acid solution has a strong pH buffering function, can neutralize or buffer gastric acid, and does not produce gas during the process, and has the effect of resisting peptic ulcer.

Related Links: Tromethamine

References: Application of an organic acid salt of tromethamine. CN109223740A [P]