In recent years, with the development of biological materials, the technical demand for surface modification of materials has become more and more extensive. Especially when the functions of tissue compatibility, biological activity, and antibacterial property of biological materials need to be improved, bio-surface modification technology, especially preparation of bio-coating, is particularly important.

In the preparation of bio-coatings, the earliest technique was depositing coatings, cold coatings or thermal coatings. However, the required equipment requirements are high, and the thermal coatings even require high temperatures. The surface of the material of the coating has some damage, and this technology is aimed at a relatively narrow range of materials, mainly metal or ceramic coatings, and the coated material objects are only metal or ceramic materials. Subsequently, a sol-gel method was used to prepare the coating, however, the preparation process was complicated and harmful to the environment. In-situ surface modification techniques have recently been reported, such as ion implantation, photolithography, and other electrochemical processes, but the process is relatively complicated. Therefore, it is necessary to develop a low-cost application technology.

The researchers [1] proposed a new medical composite material based on Tris(Hydroxymethyl) Aminomethane (TRIS), which has the characteristics of good biocompatibility, strong surface adhesion, uniform coating thickness distribution, etc. The medical composite materials can be used in the modification of pharmaceutical drugs, such as biopharmaceutical sprays.

Specifically, the following steps are included:

(2) The in-situ synthesized solution was centrifuged (rate: 5000 to 10000 rpm, time: 10 to 20 min), and the lower layer was washed with distilled water and centrifuged at least twice to dry to obtain the medical composite material. 

The coating material used in this method is a bio-coating material, and is generated when the organism itself is excited or stimulated, which has good biocompatibility. It requires simple raw materials and a synthetic process, and has low cost, and the prepared bio-coating has uniform thickness and has broad application prospects in medical sprays, medical bandages, etc., and the process is simple and the operation can meet the need of large-scale production and use, it can replace the high-temperature coating technology or the complicated chemical process previously used.

Reference

[1] Medical composite material and preparation method thereof. CN201910373557.2, 2015.08.13.