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New drug in development may make patients with diabetes away from pain!
2017-09-04

Recently, Daiichi Sankyo's official website has published an important outcome of a Phase III clinical trial of its drug Mirogabalin: Mirogabalin has a significant effect in the treatment of diabetic peripheral neuropathy (DPN) and has no major safety concerns. Diabetes is an important public health problem, according to the data from World Health Organization, there are about 400 million people a...
Comparison of Four Synthetic Methods of DPP-4 Inhibitor Saxagliptin
2017-09-01

Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor, a drug developed by Bristol-Myers Squibb Pharmaceuticals Inc. for the treatment of adult type II diabetes, which was approved by the FDA in March 2010, and by the SFDA in May 2011. It has the advantages of prominent and lasting efficacy. This paper will summarize and compare the main synthetic routes. Route 1: WO2004052850 [1] 3-hydroxyada...
High hepatic DPP-4 activity can promote NAFLD?
2022-02-15

Researchers from the University of Potsdam and the University of Tübingen have found that high levels of DPP-4 in the liver promote the formation of non-alcoholic fatty liver desease (NAFLD). The study has been published in the journal "Molecular Metabolism". DPP-4 is an enzyme secreted by the liver that decomposes proteins in the body, such as GLP-1. GLP-1 can reduce blood glucose by stimulating ...
Effects of Tris and Bicine Buffers on the In Vitro Properties of ULPs
2017-08-29

Uricase is an important enzyme in the purine metabolic pathway of the organism, which can catalyze the oxygen and uric acid to avoid gout and hyperuricemia caused by excessive accumulation of uric acid in the blood. Urease liposomes (ULPs) overcome the shortcomings of other uricase preparations by packaging drugs in the lipid bilayer, with good stability and high safety, and have a certain functio...
Gocovri was approved by FDA for the treatment of Dyskinesia in Parkinson's Disease
2017-08-28

Recently, Adamas Pharmaceuticals announced in its official website, that Gocovri (amantadine) extended release capsules (previously ADS-5102) for treatment of dyskinesia in patients with Parkinson's disease has been approved by FDA. It is the first and only medicine approved by the FDA for this indication. Parkinson's disease is a chronic neurodegenerative disease that can last for decades. As the...
What are the differences between HEPES (7365-45-9) and Tris (77-86-1) buffer?
2017-08-23

In the biochemical experiment, the buffer solution plays an indispensable role, it can resist the effect of a small amount of strong acid and alkali, and maintain the pH value the most close to the physiological environment for the system. HEPES buffer and Tris buffer are commonly used in biological experiments buffer, and many people often have doubts: What is the difference between the two? This...
Entecavir has been approved by CFDA for children
2017-08-22

Recently, Entecavir Tablet (Baraclude), developed by Bristol-Myers Squibb (BMS), has been approved by the CFDA for the treatment of patients from 2 to 18 years old with chronic hepatitis B virus infected compensatory liver disease. Hepatitis B is a kind of infectious disease caused by the hepatitis B virus, which targets the liver and can cause a variety of organ damage, it is mainly transmitted b...
The role of tris(hydroxymethyl)aminomethane (77-86-1) in eye drops
2022-02-15

Tris(hydroxymethyl)aminomethane (tromethamine, Tris) is an important organic chemical material. Tris is widely used in the pharmaceutical field, in addition to what we know as a component of buffers in biochemical experiments. For example, it is often used in eye drops. However, as people pay much attention to safety, they often have such a question: what kind of role does Tris play in eye drops? ...
Study on the Interaction of BSA and ANS and Its Conformation Changes
2022-02-15

Serum albumin (SA) is one of the most abundant proteins in the blood circulation, and has important physiological functions such as storage, transportation and organism protection. Bovine serum albumin (BSA) has been used as an ideal protein model for the study of physicochemical properties, structure and function due to the relatively small molecular weight and solubility. 8-anilino-naphthalene-1...

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